Ali Khademhosseini is a Levi Knight Professor in the Department of Bioengineering, Chemical and Biomolecular Engineering, and Department of Radiology at the University of California, Los Angeles where he directs the Center for Minimally Invasive Therapeutics (C-MIT). He is also the Associate Director for the California Nanoysystems Institute (CNSI). He is recognized as a leader in combining micro- and nano-engineering approaches with advanced biomaterials for regenerative medicine applications. In particular, his laboratory has pioneered numerous technologies and materials for controlling the architecture and function of engineered vascularized tissues. He has authored ~500 journal papers (H-index > 95, >36,800 citations) and 60 books/chapters.
His research is based on developing micro- and nanoengineering approaches for controlling cell microenvironment and to use these techniques to regulate stem cell fate decisions. Controlling cell microenvironment by developing novel micro- and nanoscale technologies to regulate cell-cell contact (using patterned co-cultures), cell-ECM interactions (using novel biomaterials), cell-soluble factor components (using microfluidics) and cell shape (using micropatterning). In addition, development of microfluidic and microarray methods to perform high-throughput experiments, in order to facilitate systematic testing of various environmental conditions on cell fate. Equipped with these tools results to generation of various aspects of stem cell self-renewal and differentiation, and development of microreactors that facilitate directed differentiation of stem cells to therapeutic cells.
Tissue engineering, Biomaterials, BioMEMS and Stem cell engineering. Organs-on-a-chip, Dr. Khademhosseini has pioneered the integrated multi-organ-on-a-chip platforms with built-in microfluidic bioreactors for construction of biomimetic organoids, physical sensors.
Available equipment and techniques:
Ali Khademhosseini’s lab is equipped with tissue culture room, 3D/Bioprinting, nano-fabrication and microscopy. He is also affilited with California NanoSystems Institute at University of California Los Angeles, which provides access to Electron Imaging Center for Nanomachines, Advanced Light Microscopy / Spectroscopy, Nano & Pico Characterization Laboratory, Molecular Screening Shared Resource, Integrated Nano Materials Laboratory, and the Integrated Systems Nanofabrication Cleanroom.